
Stigma in direction of people with psychological well being circumstances resembling despair is effectively documented (Wooden et al., 2014) and extremely frequent (see Pattie’s Psychological Elf weblog on the prevalence of self-stigma in despair). Nevertheless, the nature and route of the connection between stigma and despair has been comparatively unexplored regardless of it probably impacting approaches to remedy.
Merely put, stigma refers back to the unfavourable appraisal of an individual or group of individuals primarily based on a attribute or a part of their identification that’s frowned upon by mainstream society. Complicating issues, there are additionally various kinds of stigma, together with:
- Anticipated stigma (i.e., one’s expectation of how others will deal with them primarily based upon the identification in query)
- Enacted stigma (i.e., experiencing discrimination primarily based upon the identification or trait in query)
- Internalised or self-stigma (i.e., how one involves see oneself by means of the attitude of others; Fox et al., 2018).
Moreover, stigmatised identities could also be seen, resembling ethnicity, or concealable, resembling psychological well being circumstances (Quinn et al., 2020). That stated, some psychological well being circumstances resembling body-focused repetitive behaviors (BFRBs) even have seen components. For instance, these with BFRBs typically have evident hair-loss or pores and skin lesions (Mathew et al., 2021).
To higher perceive the connection between anticipated and internalised stigma and despair, O’Donnell and Foran (2024) undertook a scientific overview to:
- Set up whether or not anticipated and/or internalised stigma may predict ranges of despair
- Assess the standard of proof for a causal relationship between stigma and despair.

Self-stigma in folks with despair is very frequent worldwide. Exploring whether or not these with stigmatised identities are extra vulnerable to growing despair is vital to growing preventative approaches to remedy.
Strategies
Following PRISMA tips, the authors searched 4 on-line databases (together with a gray literature database) to establish research that:
- Collected quantitative knowledge
- Utilised legitimate and dependable stigma and despair measures
- Concerned individuals aged 18+ with a stigmatised identification apart from despair
- Included despair as an consequence measure
- Had been accessible in English
The authors centered on research with stigma as a predictor and despair as an consequence. Their curiosity was on the direct hyperlink between stigma and despair, not mediating results. Consequently, they excluded research that solely reported correlational analyses or confirmed a mediation diagram as an alternative of a regression desk.
The preliminary search resulted in 2000+ potential research, and screening proceeded in levels. The researchers piloted the primary 100 outcomes with two unbiased screeners, after which every researcher independently screened all titles and abstracts, resolving discrepancies by means of dialogue. They utilized the Nationwide Institutes of Well being (NIH) high quality evaluation software for observational cohort and cross-sectional research, independently score research as “good,” “passable,” or “poor” and resolving inconsistencies by means of dialogue.
Outcomes
Research traits
Eighty-three research had been included within the systematic overview. Nearly all of research had been cross-sectional (n = 73) with the second most typical kind of examine being longitudinal (n = 10). Throughout the research, there was a complete of 34,705 individuals. Most research included within the overview had been carried out in the USA (n = 39), with some illustration from Asia (n = 22), Africa (n = 9), and Europe (n = 6).
5 of the research centered completely on anticipated stigma. Sixty-one research measured internalised stigma, with an additional 9 research measuring this assemble beneath ‘self-stigma’. Eight of the included research measured each anticipated and internalised stigma.
The 83 research analysed 21 completely different stigmatised identities, which the authors organised beneath the next 5 subcategories:
- Sexual and gender minorities
- HIV/AIDS
- Sickness or disability-related (non-HIV)
- Weight
- Different
Important findings
Sixty research confirmed direct proof for a constructive hyperlink between internalised stigma and/or anticipated stigma and despair. One other 13 confirmed proof for the constructive hyperlink with some {qualifications} (i.e., didn’t present a major relationship when different variables had been thought of), 9 research contradicted the anticipated hyperlink, and one examine discovered that internalized stigma predicted decrease despair. In complete, 12% of research didn’t assist the anticipated hyperlink.
Outcomes by stigmatised identification class
- 33.7% of the research centered on the hyperlink between stigma associated to sexual or gender minority standing and despair, with roughly half (53.6%) supporting a constructive relationship between anticipated and/or internalised stigma with ranges of/chance of despair.
- 32.5% of the research examined the hyperlink between HIV/AIDS stigma and despair. 23 of the 27 research (85.2%) discovered a major constructive hyperlink between anticipated and/or internalised stigma and despair.
- 9.6% of the research centered on the hyperlink between weight stigma and despair. The entire research on this class discovered a major constructive hyperlink between anticipated and/or internalised stigma and despair.
- 15.7% of the research explored the connection between sickness or disability-related stigma and despair, with probably the most generally studied sicknesses being COVID-19 and most cancers. Given the vary of circumstances, this class lacked ample cohesion for significant quantitative evaluation and comparability.
- Much like the above, though 8.9% of included research had been categorised as “different”, there was not sufficient similarity amongst them to attract conclusions.
Outcomes by examine design
Of the 73 cross-sectional research included, the bulk (n = 56; 76.7%) supported a vital constructive relationship between internalised and/or anticipated stigma and despair.
Compared, of the ten longitudinal research reviewed, solely 4 (40%) discovered a constructive impact of internalised stigma on elevated depressive signs over time.

Of the 83 research included on this systematic overview, 60 discovered a direct constructive hyperlink between anticipated and/or internalized stigma and signs of despair.
Conclusions
This systematic overview by O’Donnell and Foran (2024) concluded that anticipated and/or internalised stigma is a predictor of despair. Proof throughout samples confirmed internalised and/or anticipated stigma to be considerably and positively linked to ranges of despair, unbiased of things resembling age, gender identification, schooling, sexual orientation, and enacted stigma, though the energy of the connection different by kind of stigmatised identification. Provided that outcomes different significantly by examine design, with cross-sectional research demonstrating a extra constant relationship than longitudinal research, the authors recommend additional examination of the impression of stigma over time.

Whereas cross-sectional research broadly assist stigma as a predictor of despair, longitudinal research present combined outcomes, highlighting the necessity for additional analysis on the connection between stigma and despair.
Strengths and limitations
Strengths
- Prior analysis has centered on internalised and enacted stigma in direction of folks with despair. This overview makes a new contribution by highlighting how pre-existing stigma can impression one’s despair, furthering our understanding of how marginalised populations expertise this psychological well being situation in distinctive methods.
- The methodological strengths of this text embrace the authors’ adherence to the NIH high quality evaluation software for commentary cohort and cross-sectional research, which was used to conduct a top quality evaluation of every included examine. Research had been of “good” or “truthful” high quality, indicating the relative reliability of the findings.
- Nearly all of research included within the overview used well-validated measures of internalised stigma, anticipated stigma, and despair, which have been used throughout all kinds of contexts and constantly present dependable outcomes measuring the supposed assemble.
Limitations
- Methodological limitations embrace the use of a scientific overview reasonably than a meta-analysis, which might enable for a extra exact estimate of impact sizes and supply extra quantitative analysis and synthesis of the info. It is usually not totally clear why the authors determined towards a meta-analysis.
- The authors didn’t embrace kappa values to point inter-rater reliability between the 2 screeners. It’s due to this fact unknown if there was good reliability between the screeners, which might enhance confidence within the findings.
- The authors didn’t elaborate on how they retrieved the recognized information, and 19 stories had been unavailable because of the authors’ requests for entry not being returned; nevertheless, they don’t make it clear how they went about attempting to acquire these stories. These stories may probably maintain necessary info in relation to the systematic overview, which may impression its validity and reliability.
- The majority of research included within the overview had been cross-sectional, that means that the authors can not make claims about how stigma impacts despair over time. Nevertheless, understanding the connection over time is vital to establishing a causal relationship, which might subsequently assist us to know what must be focused in interventions.
- Findings from longitudinal research had been completely different from the outcomes of the cross-sectional research included, indicating a weaker hyperlink between stigma and despair. Nevertheless, provided that the variety of longitudinal research included was a lot decrease than the variety of cross-sectional research, it’s tough to attract conclusions concerning the significance of this distinction. Additional analysis would profit from a extra balanced pattern.

Whereas the overview utilised well-validated measures, limitations embrace an absence of longitudinal research, and a lacking clarification as to why a meta-analysis wasn’t undertaken.
Implications for follow
The outcomes of this overview are necessary within the context of psychological well being circumstances past main depressive dysfunction. As reported by Thornicroft et al. (2016) of their Lancet Fee, psychological well being circumstances carry a double jeopardy to those that expertise the signs of their dysfunction and are topic to stigma, with the latter typically reported as feeling worse than the previous. Many therapeutic approaches nonetheless concentrate on the first signs of the dysfunction with out contemplating the impression of power stigma and disgrace. That is significantly the case for lesser-known problems, the place lack of knowledge and understanding drive increased ranges of stigma.
A living proof is body-focused repetitive behaviors (BFRBs) resembling trichotillomania (hair pulling) and dermatillomania, or excoriation dysfunction (skin-picking). These problems are related to vital stigma and depressive signs (Mathew et al., 2021), however are so stigmatized that many individuals with BFRBs who method well being professionals for assist discover that the ‘consultants’ know little to nothing about their situation (Tucker et al., 2011; Woods et al., 2006).
Moreover, whereas psychological well being circumstances are sometimes thought of a concealable stigma, it could be that folks with BFRBs expertise self-stigma in ways in which align extra with those that expertise seen stigmas resembling weight stigma. Self-stigma can delay treatment-seeking, and people with seen stigmas could have the next chance of experiencing internalised and anticipated stigma, resulting in power disgrace, which can then result in despair. These insights can inform destigmatisation efforts for clinicians and researchers to enhance medical outcomes for folks with BFRBs and different psychological well being circumstances which might be extra seen.
For clinicians, it is very important:
- Handle stigma on the outset of remedy. Self-stigma can deter treatment-seeking, in addition to intrude with remedy adherence (Kamaradova et al., 2016). Due to this fact, it is very important ask shoppers throughout evaluation about points of their identification that really feel stigmatised in an effort to proactively establish and discover methods of addressing this potential barrier.
- Construct shoppers’ consciousness of the psychological results related to holding a stigmatised identification, alongside figuring out elements that will defend towards these results.
For researchers, it is very important:
- Discover the connection between internalised and anticipated stigma in under-researched areas like BFRBs. For BRFBs, this analysis may embrace excoriation dysfunction and trichotillomania as the end result measures.
- Utilise each quantitative and qualitative strategies to discover the growth, upkeep and impression of self-stigma in people with BFRBs.
- Develop destigmatisation interventions tailor-made to these with seen stigmas resembling BFRBs.

Insights from this overview can inform destigmatisation efforts to enhance remedy outcomes for folks with different types of seen stigma resembling body-focused repetitive behaviors (BFRBs).
Assertion of pursuits
None.
Hyperlinks
Main paper
O’Donnell, A. T., & Foran, A.-M. (2024). The hyperlink between anticipated and internalized stigma and despair: A scientific overview. Social Science & Medication, 349, 116869–116869.
Different references
Fox, A. B., Earnshaw, V. A., Taverna, E. C., & Vogt, D. (2018). Conceptualizing and measuring psychological sickness stigma: The psychological sickness stigma framework and demanding overview of measures. Stigma and Well being, 3(4), 348–376.
Gonsalves, P. (2023). Self-stigma for folks with despair: systematic overview presents world prevalence knowledge, threat elements and protecting elements. The Psychological Elf.
Kamaradova, D., Latalova, Okay., Prasko, J., Kubinek, R., Vrbova, Okay., Mainerova, B., … & Tichackova, A. (2016). Connection between self-stigma, adherence to remedy, and discontinuation of remedy. Affected person Desire and Adherence, 1289-1298.
Mathew, A. S., Harvey, A. M., & Lee, H.-J. (2021). Growth of the social considerations in people with body-focused repetitive behaviors (SCIB) scale. Journal of Psychiatric Analysis, 135, 218–229.
Quinn, D. M., Camacho, G., Pan-Weisz, B., & Williams, M. Okay. (2019). Seen and concealable stigmatized identities and psychological well being: Experiences of racial discrimination and anticipated stigma. Stigma and Well being.
Thornicroft, G., Mehta, N., Clement, S., Evans-Lacko, S., Doherty, M., Rose, D., … & Henderson, C. (2016). Proof for efficient interventions to cut back mental-health-related stigma and discrimination. The Lancet, 387(10023), 1123-1132.
Tucker, B. T., Woods, D. W., Flessner, C. A., Franklin, S. A., & Franklin, M. E. (2011). The Pores and skin Choosing Influence Challenge: phenomenology, interference, and remedy utilization of pathological pores and skin selecting in a population-based pattern. Journal of Nervousness Problems, 25(1), 88-95.
Wooden, L., Birtel, M., Alsawy, S., Pyle, M., & Morrison, A. (2014). Public perceptions of stigma in direction of folks with schizophrenia, despair, and nervousness. Psychiatry Analysis, 220(1-2), 604–608.
Woods, D. W., Flessner, C. A., Franklin, M. E., Keuthen, N. J., Goodwin, R. D., Stein, D. J., & Walther, M. R. (2006). The Trichotillomania Influence Challenge (TIP): exploring phenomenology, useful impairment, and remedy utilization. Journal of Scientific Psychiatry, 67(12), 1877.
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